Announcements

14JUN

LifeSci Biotechnology Indexes: Semi-Annual Reconstitution (Final)

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Monday, June 18, 2018. All positions will be equally-weighted, with weights determined as of the closing prices on Thursday, June 14, 2018. (There are no changes to the preliminary index changes announced on June 8, 2018.) LifeSci Biotechnology Clinical Trials Index Additions (27 stocks): ADAP, ADVM, ALBO, APLS, ARQL, ARWR, BHVN, CBIO, CCXI, CLSD, DCPH, DNLI, ECYT, FATE, MNOV, PGNX, RCKT, RCUS, RYTM, SELB, SGYP, SLDB, SRNE, SYRS, TORC, VKTX, VSTM Deletions (11 stocks): AGIO, ARDX, CALA, CLDX, DOVA, JNCE, MCRB, NLNK, RARE, RIGL,

08JUN

LifeSci Biotechnology Index Semi-Annual Reconstitution (Preliminary)

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Monday, June 18, 2018. All positions will be equally-weighted, with weights determined as of the closing prices on Thursday, June 14, 2018. The preliminary changes, subject to modification, are summarized below. LifeSci Biotechnology Clinical Trials Index Additions (27 stocks): ADAP, ADVM, ALBO, APLS, ARQL, ARWR, BHVN, CBIO, CCXI, CLSD, DCPH, DNLI, ECYT, FATE, MNOV, PGNX, RCKT, RCUS, RYTM, SELB, SGYP, SLDB, SRNE, SYRS, TORC, VKTX, VSTM Deletions (11 stocks): AGIO, ARDX, CALA, CLDX, DOVA, JNCE, MCRB, NLNK, RARE, RIGL, TTPH Summary: The updated index will have 98

09MAY

Removal of Component(s) - AVXS

LifeSci Biotechnology Clinical Trials Index Removal of Component(s) – AVXS 5/9/2018 Effective at the market close on Monday, May 14, 2018, AVXS will be removed from the LifeSci Biotechnology Clinical Trials Index and its value will be redistributed to the remaining index components based on their weights. On 4/9/2018, AveXis (AVXS) announced that it will be acquired by Novartis AG for $218 per share in cash.

06FEB

Removal of Component(s) - RXDX, JUNO, BIVV

LifeSci Biotechnology Clinical Trials Index LifeSci Biotechnoloogy Products Index Removal of Component(s) – RXDX, JUNO, BIVV 2/6/2018 Effective at the market close on Thursday, February 8, 2018, RXDX and JUNO will be removed from the LifeSci Biotechnology Clinical Trials Index and their combined values will be redistributed to the remaining index components based on their weights. On 12/22/2017, Ignyta (RXDX) announced that it will be acquired by Roche for $27 per share in cash. On 1/22/2018, Juno Therapeutics (JUNO) announced that it will be acquired by Celgene for $87 per share in cash. Effective at the market close on Thursday, February 8, 2018, BIVV will be removed

14DEC

LifeSci Biotechnology Index Semi-Annual Reconstitution

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Monday, December 18, 2017. All positions will be equally-weighted, with weights determined as of the closing prices on Thursday, December 14, 2017.

22SEP

LifeScio Biotechnology Clinical Trials Index - Removal of KITE

30AUG

Virtus ETF Solutions Rebrands BioShares ETFs; Moves Listings for BBC, BBP to NYSE Arca

Virtus ETF Solutions Rebrands BioShares ETFs; Moves Listings for BBC, BBP to NYSE Arca NEW YORK, Aug. 30, 2017 /PRNewswire/ -- Virtus ETF Solutions, an affiliate of Virtus Investment Partners, Inc. (NASDAQ:VRTS) and multi-manager ETF sponsor, today announced that effective September 1, 2017, the BioShares Biotechnology Clinical Trials Fund (Ticker: BBC) and the BioShares Biotechnology Products Fund (Ticker: BBP) will change their names to the Virtus LifeSci Biotech Clinical Trials ETF and the Virtus LifeSci Biotech Products ETF, respectively, and will change their primary listing venue to NYSE Arca. The funds, which are advised by Virtus ETF Advisers, will retain their current ticker symbols when they

16JUN

BioShares Biotechnology ETFs Complete Semi-Annual Rebalance and Recomposition

New York, June 16, 2017 — LifeSci Index Partners, LLC, an affiliate company of LifeSci Advisors, and a New York City-based investment advisor and index provider, today announced the completion of its semi-annual rebalancing and recomposition for its BioShares Biotechnology exchange-traded funds (ETFs), which trade under the symbols BBC and BBP on Nasdaq. These passively-managed funds are designed to track their respective, rules-based indexes.

01MAR

LifeSci Biotechnology Clinical Trials Index - Removal of CLCD

20FEB

LifeSci Biotechnology Products Index - Removal of ARIA

16DEC

BioShares Biotechnology ETFs Complete Semi-Annual Rebalance and Recomposition

New York, December 16, 2016 — LifeSci Index Partners, LLC (“LSIP”), a New York City-based investment advisor and index provider, today announced the completion of its semi-annual rebalancing and recomposition for its BioShares Biotechnology exchange-traded funds (ETFs), which trade under the symbols BBC and BBP on Nasdaq. These passively-managed funds are designed to track their respective, rules-based indexes.

16JUN

BioShares Biotechnology ETFs Complete Semi-Annual Rebalance and Recomposition

The BioShares Biotechnology Funds are the only ETFs to separate Clinical Trials stage companies and Products stage companies into two distinct funds. The BioShares Biotechnology Clinical Trial Fund (BBC) and BioShares Biotechnology Product Fund (BBP) offer investors exposure to these two distinct segments of the biotechnology sector while diversifying some of the risks associated with any single company.

21DEC

BioShares Biotechnology Funds Announce Distribution

For Further Information: Virtus ETF Solutions etfinfo@virtus.com BioShares™ Biotechnology Products Fund and BioShares™ Biotechnology Clinical Trials Fund Announce Distribution New York, NY, December 21, 2015 – The BioShares™ Biotechnology Products Fund (Ticker: BBP) and BioShares™ Biotechnology Clinical Trials Fund (Ticker: BBC), exchange-traded funds advised by Virtus ETF Advisers, LLC and subadvised by LifeSci Index Partners, LLC, today announced a distribution on its common stock as follows: Ticker Per-Share Distribution Declaration Date Ex-Date Record Date Payable Date BBP $0.39725 12/18/2015 12/21/2015 12/23/2015 12/29/2015 BBC $0.14733 12/18/2015 12/21/2015 12/23/2015 12/29/2015 About the funds The BioShares™ Biotechnology Products Fund and BioShares™ Biotechnology Clinical Trials Fund seek investment results that correspond, before fees and expenses, to the price and yield performance of the LifeSci Biotechnology Products Index and the LifeSci

16DEC

BioShares Biotechnology ETFs Complete Semi-Annual Rebalance and Recomposition; Celebrate 1-Year Anniversary

BioShares Biotechnology ETFs Complete Semi-Annual Rebalance and Recomposition; Celebrate 1-Year Anniversary (Nasdaq: BBC, BBP) BioShares Biotechnology Funds Celebrate 1-Year Anniversary New York, December 16, 2015 — LifeSci Index Partners, LLC (“LSIP”), a New York City-based investment advisor and index provider, today announced the completion of its semi-annual rebalancing and recomposition for its BioShares Biotechnology exchange-traded funds (ETFs), which trade under the symbols BBC and BBP on Nasdaq. These passively-managed funds are designed to track their respective, rules-based indexes. The BioShares Biotechnology Funds are the only ETFs to separate Clinical Trials stage companies and Products stage companies into two distinct funds. The BioShares Biotechnology Clinical Trial

26AUG

Important Notice on Daily NAV Calculation

NOTE: Since August 24th, the Funds’ third-party administrator has been experiencing technical issues with its fund accounting software impacting its ability to calculate NAV for its ETF clients, including the Funds. As a result, the NAV we are presenting here for the Funds is the closing indicative NAV of the Funds, which represents the best available information at this time. Upon correction of the problem, these indicative NAVs will be compared to actual values, adjustments will be made and shareholders will be notified as required. Please contact the Virtus ETF Advisers help desk at 888-383-0553 for more information.