Announcements

LifeSci Biotechnology Index Semi-Annual Reconstitution (Preliminary)

June 8, 2018

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Monday, June 18, 2018. All positions will be equally-weighted, with weights determined as of the closing prices on Thursday, June 14, 2018. The preliminary changes, subject to modification, are summarized below.

LifeSci Biotechnology Clinical Trials Index

Additions (27 stocks):

ADAP, ADVM, ALBO, APLS, ARQL, ARWR, BHVN, CBIO, CCXI, CLSD, DCPH, DNLI, ECYT, FATE, MNOV, PGNX, RCKT, RCUS, RYTM, SELB, SGYP, SLDB, SRNE, SYRS, TORC, VKTX, VSTM

Deletions (11 stocks):

AGIO, ARDX, CALA, CLDX, DOVA, JNCE, MCRB, NLNK, RARE, RIGL, TTPH

Summary:

The updated index will have 98 equal-weighted components (previously 82)
As of 6/8/2018, the average market cap is approximately $1.5 billion and the median market cap is approximately $884 million

LifeSci Biotechnology Products Index

Additions (4 stocks):

AGIO, DOVA, RIGL, RARE

Deletions:

No constituents removed

Summary:

The updated index will have 42 equal-weighted components (previously 38)
As of 6/8/2018, the average market cap is approximately $14 billion and the median market cap is approximately $2.8 billion

The LifeSci Biotechnology Indexes are equal-weighted indexes that track the performance of U.S.-listed biotechnology stocks in two distinct stages in the lifecycle of biotechnology companies – Clinical Trials stage and Product stage. The indexes are calculated with a base value of 1,000 as of June 30, 2004 and have an official inception date of November 3, 2014.

LifeSci Biotechnology Clinical Trials Index – Projected Components as of June 18, 2018

ABEO, ACHN, ADAP, ADRO, ADVM, AGEN, AIMT, AKAO, AKBA, AKCA, ALBO, ALDR, ALNY, ANAB, APLS, ARNA, ARQL, ARRY, ARWR, ASMB, ATNX, ATRA, AVEO, AXON, BCRX, BGNE, BHVN, BLCM, BLUE, BOLD, BPMC, CARA, CBAY, CBIO, CCXI, CLSD, CRBP, CTMX, CYTK, DCPH, DNLI, ECYT, EPZM, ESPR, FATE, FGEN, FOLD, FPRX, GBT, GERN, GLYC, GTHX, IDRA, IMGN, IMMU, INO, INSM, IOVA, ITCI, KPTI, KURA, LJPC, LOXO, MDGL, MGNX, MLNT, MNOV, MRNS, MRTX, MYOK, NVAX, PGNX, PIRS, PRTA, PRTK, PTCT, QURE, RCKT, RCUS, RETA, RGNX, RYTM, SAGE, SELB, SGMO, SGYP, SLDB, SRNE, STML, SYRS, TGTX, TORC, VKTX, VSTM, VYGR, XLRN, XNCR, ZIOP

LifeSci Biotechnology Products Index – Projected Components as of June 18, 2018

ACAD, ACOR, AGIO, ALXN, AMGN, BIIB, BMRN, CELG, CLVS, DOVA, DVAX, ENTA, EXEL, GILD, HALO, ICPT, INCY, IONS, IRWD, KERX, LGND, LXRX, MDCO, MNTA, NBIX, NKTR, OMER, ONCE, PBYI, PTLA, RARE, RDUS, REGN, RIGL, RTRX, SGEN, SRPT, TBPH, TSRO, UTHR, VNDA, VRTX

For more information, visit www.lifesciindex.com